Berberine HCL

What is Berberine?

Berberine HCL is a naturally-occurring plant alkaloid found in herbs like Berberis aristata and Coptis chinensis. It has been used for centuries in traditional medicine and is now widely studied for its role in supporting metabolic health.

Berberine works at the cellular level to activate AMPK – an enzyme known as the body’s “metabolic master switch” – which helps regulate glucose uptake, fat metabolism, and energy production. It also promotes healthy digestion and gut microbiome balance, making it a versatile supplement for both wellness and performance.

ALLMAX Berberine features the most researched and bioavailable form: Berberine HCL*

Benefits of Berberine supplementation

Clinical studies have shown Berberine HCL supplementation [1,2,3,4,5]:

• Promotes healthy blood sugar metabolism and insulin sensitivity*

• Can contribute to maintaining a healthy weight*

• Supports immune function and the maintenance of healthy respiratory tract mucus membranes*

• Aids in maintaining beneficial bacterial balance in the gut and a healthy microbiome*

• Helps maintain healthy cholesterol levels*

^{References
[1] Dong, H., Wang, N., Zhao, L., Lu, F., Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 591654, 12 pages, 2012. doi:10.1155/2012/591654.}

^{[2] Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., … & Li, M. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. Journal of Clinical Endocrinology & Metabolism, 93(7), 2559-2565.}

^{[3] Dong, H., Zhao, Y., Zhao, L., Lu, F., The efficacy of berberine in patients with type 2 diabetes mellitus: A meta-analysis. Medicine 2017; 96: e8541.}

^{[4] Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., … & Wang, S. K. (2012). Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism, 59(2), 285-292.}

^{[5] Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., … & Wang, J. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of Ethnopharmacology, 161, 69-81.}

^{* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.}

What to avoid while taking berberine?

While taking berberine, avoid using it alongside medications that lower blood sugar, blood pressure, or cholesterol unless supervised by a healthcare provider, as it may enhance their effects. Also, avoid alcohol and grapefruit, which can interfere with metabolism and increase the risk of side effects. Pregnant or breastfeeding individuals should not use berberine.

What are berberine supplements used for?

Berberine supplements are commonly used to support healthy blood sugar levels. It improves insulin sensitivity, promotes metabolic function, and aids in cardiovascular health. They are also used to support digestive health and weight management, making them popular among individuals following strict training or wellness regimens.

Is berberine supplement safe?

Berberine supplements are generally safe for most healthy adults when taken as directed. Clinical studies support its use for metabolic and cardiovascular support; however, it’s important to consult a healthcare professional before starting berberine, especially if you are taking other medications or have pre-existing health conditions.

What are the side effects of berberine supplementation?

Common side effects of berberine may include gastrointestinal discomfort such as constipation, diarrhea, gas, or stomach cramps, especially when first starting use. In rare cases, berberine may affect liver enzymes or interact with medications. Starting with a lower dose and gradually increasing can minimize side effects.